The battle of the basement sides ended in victory for Rotherham as Delroy Facey's ninth goal of the season sealed the points for the visitors.
Rotherham's first away win since October was just reward for a plucky performance against a lacklustre Brentford side that failed to rise to the challenge of the proverbial six-pointer.
With Brentford struggling for form and focus, Rotherham shrugged off the disappointment of suffering their heaviest defeat of the season last week with the in-from Facey never far from the heart of the action.
The key to the Millers' win was a transfusion of fresh blood.
Caretaker-manager Mark Robins handed debuts to 18-year-old midfielder Jamie Yates and Norwich loanee Rossi Jarvis.
He also give 19-year-old defender Liam King his first start and was rewarded with a display full of verve.
Despite the disappointment of losing to the only team below them in the league pecking order, Brentford had begun in enterprising fashion.
But with top-scorer Jo Kuffour serving the final game of a three-match suspension, the Bees again lacked bite in the final third.
Front pairing Scott Taylor and Neil Shipperley were both guilty of spurning presentable first-half chances, with Taylor particularly culpable after poking Shipperley's lobbed pass over the bar with only visiting goalkeeper Neil Cutler to beat.
How Brentford manager Scott Fitzgerald must have wished he could call on an in-form striker like Facey.
With the quarter-hour mark approaching, Facey latched on to a speculative long ball from Ian Sharps before out-muscling Andy Frampton to lash a venomous shot past Nathan Abbey.
Charlie Ide almost pulled Brentford level shortly before half-time, but David Worrell just cleared the winger's stooping far-post header.
Rotherham continued to threaten after the interval with Ian Henderson and Facey both going before defender Sharps had a headed effort chalked off for offside.
The Bees badly needed a lift and it came in the form of Lloyd Owusu's 57th minute arrival from the bench.
Kept out by injury since last April, the Ghana international was cheered on to the pitch by the Griffin Park faithful and immediately brought fresh impetus to the home attack by flashing a header wide.
But it was never going to be enough and Rotherham ran out deserved winners.